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Risk of bias in systematic reviews of non-randomized studies of adverse cardiovascular effects of thiazolidinediones and cyclooxygenase-2 inhibitors: application of a new Cochrane risk of bias tool

Bilandzic, A. et Fitzpatrick, T. et Rosella, L. et Henry, D. (2016). Risk of bias in systematic reviews of non-randomized studies of adverse cardiovascular effects of thiazolidinediones and cyclooxygenase-2 inhibitors: application of a new Cochrane risk of bias tool. PLOS Medicine, 13 (4). DOI: 10.1371/journal.pmed.1001987.

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Résumé

Systematic reviews of the effects of healthcare interventions frequently include non-randomized studies. These are subject to confounding and a range of other biases that are seldom considered in detail when synthesizing and interpreting the results. Our aims were to assess the reliability and usability of a new Cochrane risk of bias (RoB) tool for non-randomized studies of interventions and to determine whether restricting analysis to studies with low or moderate RoB made a material difference to the results of the reviews.

Type de document: Article
Mots-clés libres: VAPEN Cardiovascular Risk of bias Thiazolidinediones Inhibitors Cyclooxygenase-2 Inhibitors
Déposé par: Veille References
Date de dépôt: 09 mars 2017 13:42
Dernière modification: 09 mars 2017 13:42
URI: http://bel.uqtr.ca/id/eprint/3037

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